Endocrine Abstracts

Introduction: Pheochromocytoma and paraganglioma are the cause of secondary hypertension, glucose intolerance, arteriosclerosis and associated with increase of mortality. In addition, 10–17% of them are reported to be malignant. Therefore, diagnosis at the early stage is important.Methods: We retrospectively analyzed the medical records of Japanese patients who were admitted to our hospital from January 2001 to December 2015. They were confirmed phe...

Introduction: Thyroglobulin (Tg) is stored in the follicular lumen of the thyroid and serves as a substrate of thyroid hormone biosynthesis. However, it was shown that Tg significantly induces thyrocyte cell growth and suppresses expression of thyroid-functional genes. Despite having such functions, molecular mechanisms of Tg action are largely unclear. We have recently demonstrated that TSH-induced thyroid cell growth is partly mediated by a downregulation of microRNAs (miRNA...

Introduction: For minimally invasive surgery of primary hyperparathyroidism (PHPT), the identification of the accurate localization is required. As preoperative diagnostic imagings, we perform ultrasound, technetium 99m-sestamibi scintigraphy and either or both of megnetic resonance imaging or computed tomography in all cases. The aim of the present study is to evaluate the clinical biochemical factors that fascilitate preoperative diagnostic imagings for localization.<p c...

Multiple endocrine neoplasia type2 (MEN 2) (OMIM 171400) is an autosomal dominant inherited cancer syndrome caused by activating mutations in the RET proto-oncogene. MEN 2 is classified into three subtypes: MEN 2A, MEN 2B and familial medullary thyroid carcinoma(FMTC). MEN 2B accounts for 5–10% of MEN2 cases. More than 95% of MEN 2B patients carry M918T mutation of RET, and 2–3% harbor A883F mutation. There has been three reports of cases with MEN 2B phenotype caused...